6,748 research outputs found
Atomic transition frequencies, isotope shifts, and sensitivity to variation of the fine structure constant for studies of quasar absorption spectra
Theories unifying gravity with other interactions suggest spatial and
temporal variation of fundamental "constants" in the Universe. A change in the
fine structure constant, alpha, could be detected via shifts in the frequencies
of atomic transitions in quasar absorption systems. Recent studies using 140
absorption systems from the Keck telescope and 153 from the Very Large
Telescope, suggest that alpha varies spatially. That is, in one direction on
the sky alpha seems to have been smaller at the time of absorption, while in
the opposite direction it seems to have been larger.
To continue this study we need accurate laboratory measurements of atomic
transition frequencies. The aim of this paper is to provide a compilation of
transitions of importance to the search for alpha variation. They are E1
transitions to the ground state in several different atoms and ions, with
wavelengths ranging from around 900 - 6000 A, and require an accuracy of better
than 10^{-4} A. We discuss isotope shift measurements that are needed in order
to resolve systematic effects in the study. The coefficients of sensitivity to
alpha-variation (q) are also presented.Comment: Includes updated version of the "alpha line" lis
Predicting lung cancer recurrence from circulating tumour DNA. Commentary on 'Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution'
No abstract available
Reduction of the size of datasets by using evolutionary feature selection: the case of noise in a modern city
Smart city initiatives have emerged to mitigate the negative effects of a very fast growth of urban areas. Most of the population in our cities are exposed to high levels of noise that generate discomfort and different health problems. These issues may be mitigated by applying different smart cities solutions, some of them require high accurate noise information to provide the best quality of serve possible. In this study, we have designed a machine learning approach based on genetic algorithms to analyze noise data captured in the university campus. This method reduces the amount of data required to classify the noise by addressing a feature selection optimization problem. The experimental results have shown that our approach improved the accuracy in 20% (achieving an accuracy of 87% with a reduction of up to 85% on the original dataset).Universidad de Málaga. Campus de Excelencia Internacional AndalucĂa Tech.
This research has been partially funded by the Spanish MINECO and FEDER projects TIN2016-81766-REDT (http://cirti.es), and TIN2017-88213-R (http://6city.lcc.uma.es)
Precalibrating an intermediate complexity climate model
Credible climate predictions require a rational quantification of uncertainty, but full Bayesian calibration requires detailed estimates of prior probability distributions and covariances, which are difficult to obtain in practice. We describe a simplified procedure, termed precalibration, which provides an approximate quantification of uncertainty in climate prediction, and requires only that uncontroversially implausible values of certain inputs and outputs are identified. The method is applied to intermediate-complexity model simulations of the Atlantic meridional overturning circulation (AMOC) and confirms the existence of a cliff-edge catastrophe in freshwaterforcing input space. When uncertainty in 14 further parameters is taken into account, an implausible, AMOC-off, region remains as a robust feature of the model dynamics, but its location is found to depend strongly on values of the other parameters
The results of compression forces applied to the isolated human calvaria
Data for the force necessary to fracture the isolated calvaria (skull cap) are not
available in the extant literature. Twenty dry adult calvaria were tested to failure
quasistatically at the vertex using a 15-kN load cell. The forces necessary to
fracture or cause diastasis of calvarial sutures were then documented and gross
examination of the specimens made. Failure forces had a mean measurement of
2772 N. Initial fractures did not cross suture lines. Prior to complete destruction
of the calvaria there were 7 specimens in which all sutures of the calvaria became
diastatic, 6 specimens in which the calvaria became diastatic along only
the coronal sutures, 2 specimens in which the calvaria became diastatic along
only the sagittal suture and 5 specimens in which there were diagonal linear
parietal bone fractures. Our hopes are that these data may contribute to the
structural design of more safer protective devices for use in our society, assist in
predicting injury and aid in the construction of treatment paradigms
Parents’ experiences of health visiting for children with Down syndrome
© MA Healthcare Limited.Children with Down syndrome have an increased likelihoodof experiencing serious health conditions. Health visitors canhave an important role in monitoring and promoting healthand development for young children with Down syndrome.This study aimed to explore parents’ experiences of healthvisiting services for children with Down syndrome. Twentyfour parents of children with Down syndrome aged 0–5 yearscompleted a brief questionnaire about the number and natureof visits from health visitors in the previous 12 months andtheir support needs. Some parents commented that otherprofessionals met the needs of their child, whereas others saidthat they would like more advice and support from healthvisitors. A further exploration of broader health serviceprovision, including health visiting, for young children withDown syndrome is needed.Peer reviewedFinal Accepted Versio
Ontologies, Mental Disorders and Prototypes
As it emerged from philosophical analyses and cognitive research, most concepts exhibit typicality effects, and resist to the efforts of defining them in terms of necessary and sufficient conditions. This holds also in the case of many medical concepts. This is a problem for the design of computer science ontologies, since knowledge representation formalisms commonly adopted in this field do not allow for the representation of concepts in terms of typical traits. However, the need of representing concepts in terms of typical traits concerns almost every domain of real world knowledge, including medical domains. In particular, in this article we take into account the domain of mental disorders, starting from the DSM-5 descriptions of some specific mental disorders. On this respect, we favor a hybrid approach to the representation of psychiatric concepts, in which ontology oriented formalisms are combined to a geometric representation of knowledge based on conceptual spaces
Ultraluminous Infrared Galaxies
At luminosities above ~10^{11} L_sun, infrared galaxies become the dominant
population of extragalactic objects in the local Universe (z < 0.5), being more
numerous than optically selected starburst and Seyfert galaxies, and QSOs at
comparable bolometric luminosity. At the highest luminosities, ultraluminous
infrared galaxies (ULIGs: L_ir > 10^{12} L_sun), outnumber optically selected
QSOs by a factor of ~1.5-2. All of the nearest ULIGs (z < 0.1) appear to be
advanced mergers that are powered by both a circumnuclear starburst and AGN,
both of which are fueled by an enormous concentration of molecular gas
(~10^{10} M_sun) that has been funneled into the merger nucleus. ULIGs may
represent a primary stage in the formation of massive black holes and
elliptical galaxy cores. The intense circumnuclear starburst that accompanies
the ULIG phase may also represent a primary stage in the formation of globular
clusters, and the metal enrichment of the intergalactic medium by gas and dust
expelled from the nucleus due to the combined forces of supernova explosions
and powerful stellar winds.Comment: LaTex, 6 pages with 4 embedded .eps figures. Postscript version plus
color plates available at
http://www.ifa.hawaii.edu/users/sanders/astroph/s186/plates.html To appear in
"Galaxy Interactions at Low and High Redshift" IAU Symposium 186, Kyoto,
Japan, eds. J.E. Barnes and D.B. Sander
A constitutive model for cytoskeletal contractility of smooth muscle cells
The constitutive model presented in this article aims to describe the main bio-chemo-mechanical features involved in the contractile response of smooth muscle cells, in which the biochemical response is modelled by extending the four-state Hai–Murphy model to isotonic contraction of the cells and the mechanical response is mainly modelled based on the phosphorylation-dependent hyperbolic relation between isotonic shortening strain rate and tension. The one-dimensional version of the model is used to simulate shortening-induced deactivation with good agreement with selected experimental measurements. The results suggest that the Hai–Murphy biochemical model neglects the strain rate effect on the kinetics of cross-bridge interactions with actin filaments in the isotonic contractions. The two-dimensional version and three-dimensional versions of the model are developed using the homogenization method under finite strain continuum mechanics framework. The two-dimensional constitutive model is used to simulate swine carotid media strips under electrical field stimulation, experimentally investigated by Singer and Murphy, and contraction of a hollow airway and a hollow arteriole buried in a soft matrix subjected to multiple calcium ion stimulations. It is found that the transverse deformation may have significant influence on the response of the swine carotid medium. In both cases, the orientation of the maximal value of attached myosin is aligned with the orientation of maximum principal stress
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